4BNL

Crystal structure of S. aureus FabI in complex with NADP and 2- phenoxy-5-(2-propenyl)phenol

Summary for 4BNL

• Entry DOI: 10.2210/pdb4bnl/pdb
• Related: 4BNF 4BNG 4BNH 4BNI 4BNJ 4BNK 4BNM 4BNN
• Descriptor: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-PHENOXY-5-(2-PROPENYL)PHENOL, ... (5 entities in total)
• Functional Keywords: oxidoreductase, short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi
• Biological source: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS
• Total number of polymer chains: 8
• Total formula weight: 258088.35

Authors

Schiebel, J.,Chang, A.,Bommineni, G.R.,Tonge, P.J.,Kisker, C.F. (deposition date: 2013-05-15, release date: 2013-06-05, Last modification date: 2023-12-20)

• Primary citation: Chang, A.,Schiebel, J.,Yu, W.,Bommineni, G.R.,Pan, P.,Baxter, M.V.,Khanna, A.,Sotriffer, C.A.,Kisker, C.F.,Tonge, P.J.; Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.; Biochemistry, 52:4217-, 2013; PubMed: 23697754; DOI: 10.1021/BI400413C

Experimental method

X-RAY DIFFRACTION (2.15 Å)