4BMK

Serine Palmitoyltransferase K265A from S. paucimobilis with bound PLP- Myriocin Aldimine

Summary for 4BMK

• Entry DOI: 10.2210/pdb4bmk/pdb
• Descriptor: SERINE PALMITOYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, Decarboxylated Myriocin, ... (5 entities in total)
• Functional Keywords: transferase-antibiotic complex, transferase, external aldimine, inhibitor, sphingolipids, natural product, antibiotic isp-1, transferase/antibiotic
• Biological source: SPHINGOMONAS PAUCIMOBILIS
• Total number of polymer chains: 2
• Total formula weight: 96081.49

Authors

Wadsworth, J.M.,Clarke, D.J.,McMahon, S.A.,Beattie, A.E.,Lowther, J.,Dunn, T.M.,Naismith, J.H.,Campopiano, D.J. (deposition date: 2013-05-09, release date: 2013-09-04, Last modification date: 2023-12-20)

• Primary citation: Wadsworth, J.M.,Clarke, D.J.,Mcmahon, S.A.,Lowther, J.P.,Beattie, A.E.,Langridge-Smith, P.R.R.,Broughton, H.B.,Dunn, T.M.,Naismith, J.H.,Campopiano, D.J.; The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin.; J.Am.Chem.Soc., 135:14276-, 2013; PubMed: 23957439; DOI: 10.1021/JA4059876

Experimental method

X-RAY DIFFRACTION (1.62 Å)