4BKZ

Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor

Summary for 4BKZ

Entry DOI	10.2210/pdb4bkz/pdb
Related	4BKY 4BL1
Descriptor	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, N-(3-aminopropyl)-8-[(3-fluorophenyl)amino]-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide (3 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	40589.93
Authors	Canevari, G.,Re Depaolini, S.,Cucchi, U.,Forte, B.,Carpinelli, P.,Bertrand, J.A. (deposition date: 2013-04-30, release date: 2013-08-21, Last modification date: 2023-12-20)
Primary citation	Canevari, G.,Re Depaolini, S.,Cucchi, U.,Bertrand, J.A.,Casale, E.,Perrera, C.,Forte, B.,Carpinelli, P.,Felder, E.R. Structural Insight Into Maternal Embryonic Leucine Zipper Kinase (Melk) Conformation and Inhibition Towards Structure- Based Drug Design. Biochemistry, 52:6380-, 2013 Cited by PubMed: 23914841 DOI: 10.1021/BI4005864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation