4BKZ

Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with a benzodipyrazole inhibitor

4BKZ の概要

関連するPDBエントリー4BKY 4BL1
分子名称MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, N-(3-aminopropyl)-8-[(3-fluorophenyl)amino]-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide (3 entities in total)
機能のキーワードtransferase
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数1
分子量合計40589.94
構造登録者
Canevari, G.,Re Depaolini, S.,Cucchi, U.,Forte, B.,Carpinelli, P.,Bertrand, J.A. (登録日: 2013-04-30, 公開日: 2013-08-21, 最終更新日: 2019-04-24)
主引用文献
Canevari, G.,Re Depaolini, S.,Cucchi, U.,Bertrand, J.A.,Casale, E.,Perrera, C.,Forte, B.,Carpinelli, P.,Felder, E.R.
Structural Insight Into Maternal Embryonic Leucine Zipper Kinase (Melk) Conformation and Inhibition Towards Structure- Based Drug Design.
Biochemistry, 52:6380-, 2013
PubMed: 23914841 (主引用文献が同じPDBエントリー)
DOI: 10.1021/BI4005864
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24270 5.4% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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