4BKS
von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-1-ethanoyl-N-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide
Summary for 4BKS
Entry DOI | 10.2210/pdb4bks/pdb |
Related | 4BKT |
Descriptor | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (7 entities in total) |
Functional Keywords | protein transport, e3 ubiquitin ligase, fragment based drug discovery |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus (Probable): Q15370 Q15369 Q15370 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337 |
Total number of polymer chains | 12 |
Total formula weight | 167760.63 |
Authors | Van Molle, I.,Dias, D.M.,Baud, M.,Galdeano, C.,Geraldes, C.F.G.C.,Ciulli, A. (deposition date: 2013-04-29, release date: 2013-11-27, Last modification date: 2014-01-29) |
Primary citation | Dias, D.M.,Van Molle, I.,Baud, M.G.J.,Galdeano, C.,Geraldes, C.F.G.C.,Ciulli, A. Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions? Acs Med.Chem.Lett., 5:23-, 2014 Cited by PubMed: 24436777DOI: 10.1021/ML400296C PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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