4BJX
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)
Summary for 4BJX
Entry DOI | 10.2210/pdb4bjx/pdb |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid (3 entities in total) |
Functional Keywords | dna binding protein, inhibitor, histone, epigenetic reader |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 18374.40 |
Authors | Chung, C. (deposition date: 2013-04-20, release date: 2013-10-02, Last modification date: 2024-05-08) |
Primary citation | Wyce, A.,Ganji, G.,Smitheman, K.N.,Chung, C.,Korenchuk, S.,Bai, Y.,Barbash, O.,Le, B.,Craggs, P.D.,Mccabe, M.T.,Kennedy-Wilson, K.M.,Sanchez, L.V.,Gosmini, R.L.,Parr, N.,Mchugh, C.F.,Dhanak, D.,Prinjha, R.K.,Auger, K.R.,Tummino, P.J. Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models. Plos One, 8:72967-, 2013 Cited by PubMed: 24009722DOI: 10.1371/JOURNAL.PONE.0072967 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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