4BJX

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

4BJX の概要

• エントリーDOI: 10.2210/pdb4bjx/pdb
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 4, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid (3 entities in total)
• 機能のキーワード: dna binding protein, inhibitor, histone, epigenetic reader
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18374.40

構造登録者

Chung, C. (登録日: 2013-04-20, 公開日: 2013-10-02, 最終更新日: 2024-05-08)

• 主引用文献: Wyce, A.,Ganji, G.,Smitheman, K.N.,Chung, C.,Korenchuk, S.,Bai, Y.,Barbash, O.,Le, B.,Craggs, P.D.,Mccabe, M.T.,Kennedy-Wilson, K.M.,Sanchez, L.V.,Gosmini, R.L.,Parr, N.,Mchugh, C.F.,Dhanak, D.,Prinjha, R.K.,Auger, K.R.,Tummino, P.J.; Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models.; Plos One, 8:72967-, 2013; PubMed: 24009722; DOI: 10.1371/JOURNAL.PONE.0072967

実験手法

X-RAY DIFFRACTION (1.59 Å)