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4BGH

Crystal Structure of CDK2 in complex with pan-CDK Inhibitor

Summary for 4BGH
Entry DOI10.2210/pdb4bgh/pdb
DescriptorCYCLIN-DEPENDENT KINASE 2, 4-((5-BROMO-4-(PROP-2-YN-1-YLAMINO)PYRIMIDIN-2-YL)AMINO)BENZENESULFONAMIDE (3 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains1
Total formula weight34378.75
Authors
Primary citationLucking, U.,Jautelat, R.,Kruger, M.,Brumby, T.,Lienau, P.,Schafer, M.,Briem, H.,Schulze, J.,Hillisch, A.,Reichel, A.,Wengner, A.M.,Siemeister, G.
The Lab Oddity Prevails: Discovery of Pan-Cdk Inhibitor (R)- S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-Hydroxy-1-Methylpropyl]Oxy}-5-(Trifluoromethyl)Pyrimidin-2-Yl]Amino}Phenyl)Sulfoximide (Bay 1000394) for the Treatment of Cancer.
Chemmedchem, 8:1067-, 2013
Cited by
PubMed: 23671017
DOI: 10.1002/CMDC.201300096
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

건을2024-03-27부터공개중

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