4BFI
Structure of the complex of the extracellular portions of mouse CD200R and mouse CD200
Summary for 4BFI
| Entry DOI | 10.2210/pdb4bfi/pdb |
| Related | 4BFE 4BFG |
| Descriptor | CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1, OX-2 MEMBRANE GLYCOPROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | immune system, paired receptor, ig domains, viral mimicry, leukaemia mimicry, leukaemia |
| Biological source | MUS MUSCULUS (HOUSE MOUSE) More |
| Total number of polymer chains | 2 |
| Total formula weight | 49921.57 |
| Authors | Hatherley, D.,Lea, S.M.,Johnson, S.,Barclay, A.N. (deposition date: 2013-03-19, release date: 2013-05-01, Last modification date: 2024-11-06) |
| Primary citation | Hatherley, D.,Lea, S.M.,Johnson, S.,Barclay, A.N. Structures of Cd200/Cd200 Receptor Family and Implications for Topology, Regulation, and Evolution Structure, 21:820-, 2013 Cited by PubMed Abstract: CD200 is a widely distributed membrane glycoprotein that regulates myeloid cell activity through its interaction with an inhibitory receptor (CD200R). The interaction is of interest as a target for treating excessive inflammation and for treating leukemia. There are closely related proteins to CD200R that give activating signals making this a "paired receptor." We report X-ray crystallography structures for the inhibitory CD200R, the activating receptor CD200RLa, and a complex between CD200R and CD200. Both CD200 and CD200R contain two Ig-like domains and interact through their NH₂ terminal domains compatible with immunological synapse-like interactions occurring between myeloid cells and other CD200-expressing cells. The failure of the activating receptor to bind CD200 resides in subtle changes around the interface. CD200 has been acquired by herpes viruses to mimic the host interaction. CD200R has evolved rapidly presumably driven by pathogen pressure but it may also be important in homeostasis through interactions with commensal bacteria. PubMed: 23602662DOI: 10.1016/J.STR.2013.03.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
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