4BBP

X-ray structure of zinc bound ZnuA in complex with RDS51

4BBP の概要

• エントリーDOI: 10.2210/pdb4bbp/pdb
• 分子名称: ZINC ABC TRANSPORTER, PERIPLASMIC ZINC-BINDING PROTEIN, 1-[(2-chlorophenyl)methyl]-N-hydroxy-4-phenyl-1H-pyrrole-3-carboxamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: transport protein, zinc transport inhibition
• 由来する生物種: SALMONELLA ENTERICA
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32340.09

構造登録者

Alaleona, F.,Ilari, A.,Di Santo, R.,Battistoni, A.,Chiancone, E. (登録日: 2012-09-27, 公開日: 2013-10-16, 最終更新日: 2024-10-23)

主引用文献

Ilari, A.,Pescatori, L.,Di Santo, R.,Battistoni, A.,Ammendola, S.,Falconi, M.,Berlutti, F.,Valenti, P.,Chiancone, E.
Salmonella Enterica Serovar Typhimurium Growth is Inhibited by the Concomitant Binding of Zn(II) and a Pyrrolyl-Hydroxamate to Znua, the Soluble Component of the Znuabc Transporter.
Biochim.Biophys.Acta, 1860:534-, 2016

PubMed Abstract: Under conditions of Zn(II) deficiency, the most relevant high affinity Zn(II) transport system synthesized by many Gram-negative bacteria is the ZnuABC transporter. ZnuABC is absent in eukaryotes and plays an important role in bacterial virulence. Consequently, ZnuA, the periplasmic component of the transporter, appeared as a good target candidate to find new compounds able to contrast bacterial growth by interfering with Zn(II) uptake.

PubMed: 26691136
DOI: 10.1016/J.BBAGEN.2015.12.006

実験手法

X-RAY DIFFRACTION (2.15 Å)