4BBM

CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312

Summary for 4BBM

Entry DOI	10.2210/pdb4bbm/pdb
Related	4AAA
Descriptor	CYCLIN-DEPENDENT KINASE-LIKE 2, 4'-[5-[[3-[(CYCLOPROPYLAMINO)METHYL]PHENYL]AMINO]-1H-PYRAZOL-3-YL]-[1,1'-BIPHENYL]-2,4-DIOL, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	transferase, phospho-mimetic
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q92772
Total number of polymer chains	2
Total formula weight	77925.06
Authors	Canning, P.,Elkins, J.M.,Cooper, C.D.O.,Mahajan, P.,Daga, N.,Berridge, G.,Burgess-Brown, N.,Muniz, J.R.C.,Krojer, T.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A. (deposition date: 2012-09-26, release date: 2012-10-17, Last modification date: 2023-12-20)
Primary citation	Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175 DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation