4BB5

Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors

4BB5 の概要

• エントリーDOI: 10.2210/pdb4bb5/pdb
• 関連するPDBエントリー: 1XU7 1XU9 2BEL 4BB6
• 分子名称: CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 134403.10

構造登録者

Goldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C. (登録日: 2012-09-20, 公開日: 2012-11-28, 最終更新日: 2024-05-08)

• 主引用文献: Goldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C.; Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors; J.Med.Chem., 55:10652-, 2012; PubMed: 23153367; DOI: 10.1021/JM3013163

実験手法

X-RAY DIFFRACTION (2.2 Å)