4B8X

Near atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolor

4B8X の概要

• エントリーDOI: 10.2210/pdb4b8x/pdb
• 分子名称: POSSIBLE MARR-TRANSCRIPTIONAL REGULATOR, CHLORIDE ION (3 entities in total)
• 機能のキーワード: transcription, winged helix motif
• 由来する生物種: STREPTOMYCES COELICOLOR
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31857.48

構造登録者

Holley, T.A.,Stevenson, C.E.M.,Bibb, M.J.,Lawson, D.M. (登録日: 2012-08-31, 公開日: 2012-10-17, 最終更新日: 2024-11-06)

主引用文献

Holley, T.A.,Stevenson, C.E.M.,Bibb, M.J.,Lawson, D.M.
High Resolution Crystal Structure of Sco5413, a Widespread Actinomycete Marr Family Transcriptional Regulator of Unknown Function.
Proteins, 81:176-, 2013

PubMed Abstract: The crystal structure of Sco5413 from Streptomyces coelicolor A3(2) has been determined at 1.25 Å resolution, the highest resolution reported for a MarR family transcriptional regulator. Putative orthologs are encoded by the majority of sequenced actinomycete genomes, and may play roles in regulating growth and antibiotic production, but they have yet to be assigned a precise function. Sco5413 forms a homodimer and, through comparisons with other MarR family protein structures, we postulate that it adopts a conformation compatible with DNA binding, and that a channel at the dimer interface, lined by well-conserved residues, is the binding site of an unidentified effector ligand.

PubMed: 23042442
DOI: 10.1002/PROT.24197

実験手法

X-RAY DIFFRACTION (1.25 Å)