4B8U
Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N- isobutyl-2-(5-(2-thienyl)-1,2-oxazol-3-yl-)methoxy)acetamide
Summary for 4B8U
Entry DOI | 10.2210/pdb4b8u/pdb |
Related | 4B0B 4B0C 4B0I 4B0J 4FQ9 |
Descriptor | 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-isobutyl-2-{[5-(thiophen-2-yl)-1,2-oxazol-3-yl]methoxy}acetamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | lyase, fatty acid biosynthesis, inhibitor, bacterial virulence, drug discovery |
Biological source | PSEUDOMONAS AERUGINOSA |
Cellular location | Cytoplasm (By similarity): O33877 |
Total number of polymer chains | 5 |
Total formula weight | 94233.10 |
Authors | Moynie, L.,McMahon, S.A.,Duthie, F.G.,Brenk, R.,Naismith, J.H. (deposition date: 2012-08-30, release date: 2012-09-26, Last modification date: 2023-12-20) |
Primary citation | Moynie, L.,Leckie, S.M.,Mcmahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H. Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa. J.Mol.Biol., 425:365-, 2013 Cited by PubMed: 23174186DOI: 10.1016/J.JMB.2012.11.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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