4B7Q

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

4B7Q の概要

• エントリーDOI: 10.2210/pdb4b7q/pdb
• 関連するPDBエントリー: 4B7J 4B7M 4B7N 4B7R
• 分子名称: NEURAMINIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZANAMIVIR, ... (5 entities in total)
• 機能のキーワード: hydrolase, neuraminidase inhibitor, nai, nais, oseltamivir, antiviral resistance
• 由来する生物種: INFLUENZA A VIRUS (A/CALIFORNIA/07/2009(H1N1))
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 209854.00

構造登録者

Liu, J.,van der Vries, E.,Vachieri, S.G.,Xiong, X.,Collins, P.J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J. (登録日: 2012-08-21, 公開日: 2012-10-03, 最終更新日: 2020-07-29)

• 主引用文献: Van Der Vries, E.,Collins, P.J.,Vachieri, S.G.,Xiong, X.,Liu, J.,Walker, P.A.,Haire, L.F.,Hay, A.J.,Schutten, M.,Osterhaus, A.D.M.E.,Martin, S.R.,Boucher, C.A.B.,Skehel, J.J.,Gamblin, S.J.; H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis; Plos Pathog., 8:2914-, 2012; PubMed: 23028314; DOI: 10.1371/JOURNAL.PPAT.1002914

実験手法

X-RAY DIFFRACTION (2.728 Å)