4B4A

Structure of the TatC core of the twin arginine protein translocation system

4B4A の概要

• エントリーDOI: 10.2210/pdb4b4a/pdb
• 分子名称: SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, Lauryl Maltose Neopentyl Glycol (2 entities in total)
• 機能のキーワード: transport protein, tat secretion system, protein translocation
• 由来する生物種: AQUIFEX AEOLICUS
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein (By similarity): O67305
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29427.77

構造登録者

Rollauer, S.E.,Tarry, M.J.,Jaaskelainen, M.,Graham, J.E.,Jaeger, F.,Krehenbrink, M.,Roversi, P.,McDowell, M.A.,Stansfeld, P.J.,Johnson, S.,Liu, S.M.,Lukey, M.J.,Marcoux, J.,Robinson, C.V.,Sansom, M.S.,Palmer, T.,Hogbom, M.,Berks, B.C.,Lea, S.M. (登録日: 2012-07-30, 公開日: 2012-12-05, 最終更新日: 2024-11-13)

主引用文献

Rollauer, S.E.,Tarry, M.J.,Graham, J.E.,Jaaskelainen, M.,Jager, F.,Johnson, S.,Krehenbrink, M.,Liu, S.,Lukey, M.J.,Marcoux, J.,Mcdowell, M.A.,Rodriguez, F.,Roversi, P.,Stansfeld, P.J.,Robinson, C.V.,Sansom, M.S.P.,Palmer, T.,Hogbom, M.,Berks, B.C.,Lea, S.M.
Structure of the Tatc Core of the Twin-Arginine Protein Transport System.
Nature, 49:210-, 2012

PubMed Abstract: The twin-arginine translocation (Tat) pathway is one of two general protein transport systems found in the prokaryotic cytoplasmic membrane and is conserved in the thylakoid membrane of plant chloroplasts. The defining, and highly unusual, property of the Tat pathway is that it transports folded proteins, a task that must be achieved without allowing appreciable ion leakage across the membrane. The integral membrane TatC protein is the central component of the Tat pathway. TatC captures substrate proteins by binding their signal peptides. TatC then recruits TatA family proteins to form the active translocation complex. Here we report the crystal structure of TatC from the hyperthermophilic bacterium Aquifex aeolicus. This structure provides a molecular description of the core of the Tat translocation system and a framework for understanding the unique Tat transport mechanism.

PubMed: 23201679
DOI: 10.1038/NATURE11683

実験手法

X-RAY DIFFRACTION (3.5 Å)