4B1F

Design of Inhibitors of Helicobacter pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty

Summary for 4B1F

• Entry DOI: 10.2210/pdb4b1f/pdb
• Related: 2JFX 2JFY 2JFZ 2W4I
• Descriptor: GLUTAMATE RACEMASE, 5-methyl-3-(1-methyl-1H-imidazol-5-yl)-7-(2-methylpropyl)-2-(naphthalen-1-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione, D-GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: isomerase, improved bioavailability
• Biological source: HELICOBACTER PYLORI
• Total number of polymer chains: 2
• Total formula weight: 58243.67

Authors

Basarab, G.S.,Hill, P.,Eyermann, C.J.,Gowravaram, M.,Kack, H.,Osimoni, E. (deposition date: 2012-07-10, release date: 2012-07-18, Last modification date: 2018-05-02)

• Primary citation: Basarab, G.S.,Hill, P.,Eyermann, C.J.,Gowravaram, M.,Kack, H.,Osimoni, E.; Design of Inhibitors of Helicobacter Pylori Glutamate Racemase as Selective Antibacterial Agents: Incorporation of Imidazoles Onto a Core Pyrazolopyrimidinedione Scaffold to Improve Bioavailabilty.; Bioorg.Med.Chem.Lett., 22:5600-, 2012; PubMed: 22877632; DOI: 10.1016/J.BMCL.2012.07.004

Experimental method

X-RAY DIFFRACTION (2.05 Å)