4B0J

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 5-(2- thienyl)-3-isoxazolyl methanol

Summary for 4B0J

Entry DOI	10.2210/pdb4b0j/pdb
Related	4B0B 4B0C 4B0I
Descriptor	3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, (5-thiophen-2-ylisoxazol-3-yl)methanol (3 entities in total)
Functional Keywords	lyase, fatty acid biosynthesis, bacterial virulence, drug discovery
Biological source	PSEUDOMONAS AERUGINOSA
Total number of polymer chains	20
Total formula weight	378994.90
Authors	Moynie, L.,McMahon, S.A.,Duthie, F.G.,Naismith, J.H. (deposition date: 2012-07-02, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citation	Moynie, L.,Leckie, S.M.,Mcmahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H. Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas Aeruginosa J.Mol.Biol., 425:365-377, 2013 Cited by PubMed: 23174186 DOI: 10.1016/J.JMB.2012.11.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation