4B0I
Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) mutant (H70N) from Pseudomonas aeruginosa in complex with 3-hydroxydecanoyl-N-acetyl cysteamine
Summary for 4B0I
Entry DOI | 10.2210/pdb4b0i/pdb |
Related | 4B0B 4B0C 4B0J 4B8U 4FQ9 |
Descriptor | 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, S-[2-(acetylamino)ethyl] (3R)-3-hydroxydecanethioate (3 entities in total) |
Functional Keywords | lyase, fatty acid biosynthesis, bacterial virulence, drug discovery |
Biological source | PSEUDOMONAS AERUGINOSA |
Cellular location | Cytoplasm (By similarity): O33877 |
Total number of polymer chains | 5 |
Total formula weight | 95169.61 |
Authors | Moynie, L.,McMahon, S.A.,Leckie, S.M.,Duthie, F.G.,Koehnke, A.,Naismith, J.H. (deposition date: 2012-07-02, release date: 2012-11-28, Last modification date: 2023-12-20) |
Primary citation | Moynie, L.,Leckie, S.M.,Mcmahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H. Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas Aeruginosa J.Mol.Biol., 425:365-, 2013 Cited by PubMed: 23174186DOI: 10.1016/J.JMB.2012.11.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
Download full validation report