4B0B

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 3-(pyridin-2-yloxy)aniline

4B0B の概要

• エントリーDOI: 10.2210/pdb4b0b/pdb
• 関連するPDBエントリー: 4B0C 4B0I 4B8U 4FQ9
• 分子名称: 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, 3-(pyridin-2-yloxy)aniline (3 entities in total)
• 機能のキーワード: lyase, fatty acid biosynthesis, bacterial virulence, drug discovery
• 由来する生物種: PSEUDOMONAS AERUGINOSA
• 細胞内の位置: Cytoplasm (By similarity): O33877
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37909.49

構造登録者

Moynie, L.,McMahon, S.A.,Duthie, F.G.,Taylor, J.W.,Naismith, J.H. (登録日: 2012-07-01, 公開日: 2012-11-28, 最終更新日: 2023-12-20)

• 主引用文献: Moynie, L.,Leckie, S.M.,McMahon, S.A.,Duthie, F.G.,Koehnke, A.,Taylor, J.W.,Alphey, M.S.,Brenk, R.,Smith, A.D.,Naismith, J.H.; Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa.; J.Mol.Biol., 425:365-, 2013; PubMed: 23174186; DOI: 10.1016/J.JMB.2012.11.017

実験手法

X-RAY DIFFRACTION (1.9 Å)