4B03

6A Electron cryomicroscopy structure of immature Dengue virus serotype 1

4B03 の概要

• エントリーDOI: 10.2210/pdb4b03/pdb
• 関連するPDBエントリー: 4AZX
• EMDBエントリー: 2141 2142
• 分子名称: DENGUE VIRUS 1 E PROTEIN, DENGUE VIRUS 1 PRM PROTEIN (2 entities in total)
• 機能のキーワード: virus, flavivirus, prm protein
• 由来する生物種: DENGUE VIRUS 1; 詳細
• 細胞内の位置: Virion membrane ; Multi-pass membrane protein : G3F5K5 G3F5K5
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 216960.14

構造登録者

Kostyuchenko, V.A.,Zhang, Q.,Tan, L.C.,Ng, T.S.,Lok, S.M. (登録日: 2012-06-28, 公開日: 2013-06-05, 最終更新日: 2024-05-08)

主引用文献

Kostyuchenko, V.A.,Zhang, Q.,Tan, J.L.,Ng, T.S.,Lok, S.M.
Immature and Mature Dengue Serotype 1 Virus Structures Provide Insight Into the Maturation Process.
J.Virol., 87:7700-, 2013

PubMed Abstract: Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.

PubMed: 23637416
DOI: 10.1128/JVI.00197-13

実験手法

ELECTRON MICROSCOPY (6 Å)