4AWM

Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea

Summary for 4AWM

• Entry DOI: 10.2210/pdb4awm/pdb
• Related: 4AVG 4AVL 4AVQ 4AWF 4AWG 4AWH 4AWK
• Descriptor: POLYMERASE PA, MANGANESE (II) ION, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, ... (4 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase, manganese-dependent, pd...d-e...k superfamily, hydrolase/inhibitor
• Biological source: INFLUENZA A VIRUS
• Total number of polymer chains: 1
• Total formula weight: 23495.29

Authors

Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S. (deposition date: 2012-06-04, release date: 2012-08-22, Last modification date: 2023-12-20)

• Primary citation: Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S.; Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.; Plos Pathog., 8:2831-, 2012; PubMed: 22876177; DOI: 10.1371/JOURNAL.PPAT.1002831

Experimental method

X-RAY DIFFRACTION (2.6 Å)