4AWF

Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid DPBA

Summary for 4AWF

Entry DOI	10.2210/pdb4awf/pdb
Related	4AVG 4AVL 4AVQ 4AWG 4AWH 4AWK 4AWM
Descriptor	POLYMERASE PA, MANGANESE (II) ION, 2-4-DIOXO-4-PHENYLBUTANOIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase-inhibitor complex, hydrolase, manganese-dependent, hydrolase/inhibitor
Biological source	INFLUENZA A VIRUS
Total number of polymer chains	4
Total formula weight	96965.34
Authors	Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S. (deposition date: 2012-06-03, release date: 2012-08-22, Last modification date: 2023-12-20)
Primary citation	Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S. Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8:2831-, 2012 Cited by PubMed: 22876177 DOI: 10.1371/JOURNAL.PPAT.1002831 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation