4AUT

Crystal structure of the tuberculosis drug target Decaprenyl- Phosphoryl-beta-D-Ribofuranose-2-oxidoreductase (DprE1) from Mycobacterium smegmatis

Summary for 4AUT

Entry DOI	10.2210/pdb4aut/pdb
Descriptor	DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	oxidoreductase, tuberculosis, benzothiazinone, mycobacteria
Biological source	MYCOBACTERIUM SMEGMATIS
Total number of polymer chains	1
Total formula weight	51976.44
Authors	Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.,Riccardi, G.,Mattevi, A.,Dyson, P.J.,Cole, S.T.,Binda, C. (deposition date: 2012-05-21, release date: 2012-09-05, Last modification date: 2023-12-20)
Primary citation	Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.P.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.R.,Mckinney, J.D.,Dyson, P.J.,Riccardi, G.,Mattevi, A.,Cole, S.T.,Binda, C. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis. Sci. Transl. Med., 4:121-, 2012 Cited by PubMed: 22956199 DOI: 10.1126/SCITRANSLMED.3004395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation