4AKR
Crystal Structure of the cytoplasmic actin capping protein Cap32_34 from Dictyostelium discoideum
Summary for 4AKR
| Entry DOI | 10.2210/pdb4akr/pdb |
| Descriptor | F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA, F-ACTIN-CAPPING PROTEIN SUBUNIT BETA (3 entities in total) |
| Functional Keywords | actin-binding protein |
| Biological source | DICTYOSTELIUM DISCOIDEUM (SLIME MOLD) More |
| Cellular location | Cytoplasm, cytoskeleton (By similarity): P13021 |
| Total number of polymer chains | 4 |
| Total formula weight | 128137.32 |
| Authors | Eckert, C.,Goretzki, A.,Faberova, M.,Kollmar, M. (deposition date: 2012-02-28, release date: 2012-07-04, Last modification date: 2023-12-20) |
| Primary citation | Eckert, C.,Goretzki, A.,Faberova, M.,Kollmar, M. Conservation and Divergence between Cytoplasmic and Muscle-Specific Actin Capping Proteins: Insights from the Crystal Structure of Cytoplasmic CAP32/34 from Dictyostelium Discoideum. Bmc Struct.Biol., 12:12-, 2012 Cited by PubMed Abstract: Capping protein (CP), also known as CapZ in muscle cells and Cap32/34 in Dictyostelium discoideum, plays a major role in regulating actin filament dynamics. CP is a ubiquitously expressed heterodimer comprising an α- and β-subunit. It tightly binds to the fast growing end of actin filaments, thereby functioning as a "cap" by blocking the addition and loss of actin subunits. Vertebrates contain two somatic variants of CP, one being primarily found at the cell periphery of non-muscle tissues while the other is mainly localized at the Z-discs of skeletal muscles. PubMed: 22657106DOI: 10.1186/1472-6807-12-12 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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