4AII

Crystal structure of the rat REM2 GTPase - G domain bound to GDP

4AII の概要

• エントリーDOI: 10.2210/pdb4aii/pdb
• 分子名称: GTP-BINDING PROTEIN REM 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: gtp-binding protein, rgk proteins
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane: Q9WTY2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41242.39

構造登録者

Reymond, P.,Coquard, A.,Chenon, M.,Zeghouf, M.,El Marjou, A.,Thompson, A.,Menetrey, J. (登録日: 2012-02-10, 公開日: 2012-06-13, 最終更新日: 2023-12-20)

主引用文献

Reymond, P.,Coquard, A.,Chenon, M.,Zeghouf, M.,El Marjou, A.,Thompson, A.,Menetrey, J.
Structure of the Gdp-Bound G Domain of the Rgk Protein Rem2.
Acta Crystallogr.,Sect.F, 68:626-, 2012

PubMed Abstract: RGK proteins are atypical small GTP-binding proteins that are involved in the regulation of voltage-dependent calcium channels and actin cytoskeleton remodelling. The structure of the Rem2 G domain bound to GDP is reported here in a monoclinic crystal form at 2.66 Å resolution. It is very similar to the structure determined previously from an orthorhombic crystal form. However, differences in the crystal-packing environment revealed that the switch I and switch II regions are flexible and not ordered as previously reported. Comparison of the available RGK protein structures along with those of other small GTP-binding proteins highlights two structural features characteristic of this atypical family and suggests that the conserved tryptophan residue in the DXWEX motif may be a structural determinant of the nucleotide-binding affinity.

PubMed: 22684057
DOI: 10.1107/S1744309112013541

実験手法

X-RAY DIFFRACTION (2.66 Å)