4AH9

Parallel screening of a low molecular weight compound library: do differences in methodology affect hit identification

4AH9 の概要

• エントリーDOI: 10.2210/pdb4ah9/pdb
• 関連するPDBエントリー: 4AHR 4AHS 4AHT 4AHU 4AHV
• 分子名称: INTEGRASE, 1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)-1,4-DIAZEPANE, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: transferase, fragment screening
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS (HIV)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42781.73

構造登録者

Wielens, J.,Heady, S.J.,Rhodes, D.I.,Mulder, R.J.,Dolezal, O.,Deadman, J.J.,Newman, J.,Chalmers, D.K.,Parker, M.W.,Peat, T.S.,Scanlon, M.J. (登録日: 2012-02-06, 公開日: 2012-12-19, 最終更新日: 2023-12-20)

• 主引用文献: Wielens, J.,Headey, S.J.,Rhodes, D.I.,Mulder, R.J.,Dolezal, O.,Deadman, J.J.,Newman, J.,Chalmers, D.K.,Parker, M.W.,Peat, T.S.,Scanlon, M.J.; Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?; J.Biomol.Screen, 18:147-, 2013; PubMed: 23139382; DOI: 10.1177/1087057112465979

実験手法

X-RAY DIFFRACTION (1.7 Å)