4AEY

Crystal structure of FolX from Pseudomonas aeruginosa

Summary for 4AEY

Entry DOI	10.2210/pdb4aey/pdb
Descriptor	D-ERYTHRO-7,8-DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE (2 entities in total)
Functional Keywords	isomerase, pteridine biosynthesis
Biological source	PSEUDOMONAS AERUGINOSA
Total number of polymer chains	1
Total formula weight	18011.76
Authors	Gabrielsen, M.,Beckham, K.S.H.,Roe, A.J. (deposition date: 2012-01-13, release date: 2012-03-21, Last modification date: 2023-12-20)
Primary citation	Gabrielsen, M.,Beckham, K.S.H.,Cogdell, R.J.,Byron, O.,Roe, A.J. Folx from Pseudomonas Aeruginosa is Octameric in Both Crystal and Solution. FEBS Lett., 586:1160-, 2012 Cited by PubMed Abstract: FolX encodes an epimerase that forms one step of the tetrahydrofolate biosynthetic pathway, which is of interest as it is an established target for important drugs. Here we report the crystal structure of FolX from the bacterial opportunistic pathogen Pseudomonas aeruginosa, as well as a detailed analysis of the protein in solution, using analytical ultracentrifugation (AUC) and small-angle X-ray scattering (SAXS). In combination, these techniques confirm that the protein is an octamer both in the crystal structure, and in solution. PubMed: 22575651 DOI: 10.1016/J.FEBSLET.2012.03.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation