4ADP

HCV-J6 NS5B POLYMERASE V405I MUTANT

Summary for 4ADP

Entry DOI	10.2210/pdb4adp/pdb
Descriptor	RNA-DIRECTED RNA POLYMERASE (2 entities in total)
Functional Keywords	hepacivirus, nonstructural proteins, replication, transferase, rna-directed rna polymerase, rdrp, de novo initiation, priming
Biological source	HEPATITIS C VIRUS (HCV)
Total number of polymer chains	1
Total formula weight	64579.09
Authors	Scrima, N.,Bressanelli, S. (deposition date: 2012-01-02, release date: 2012-05-02, Last modification date: 2023-12-20)
Primary citation	Scrima, N.,Caillet-Saguy, C.,Ventura, M.,Harrus, D.,Astier-Gin, T.,Bressanelli, S. Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405. J.Virol., 86:7107-, 2012 Cited by PubMed: 22532694 DOI: 10.1128/JVI.00459-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.902 Å)

Structure validation