4ADF

CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1

4ADF の概要

• エントリーDOI: 10.2210/pdb4adf/pdb
• 関連するPDBエントリー: 1HMC
• 分子名称: SECRETED PROTEIN BARF1, MACROPHAGE COLONY-STIMULATING FACTOR 1, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: immune system-receptor complex, rtkiii, extracellular, cytokine receptor-cytokine complex, four-helix bundle, glycoprotein, immunoglobulin domain, oncogene, cytokine/signaling, immune system/receptor
• 由来する生物種: HUMAN HERPESVIRUS 4; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 508246.04

構造登録者

Elegheert, J.,Bracke, N.,Savvides, S.N. (登録日: 2011-12-23, 公開日: 2012-08-22, 最終更新日: 2023-12-20)

• 主引用文献: Elegheert, J.,Bracke, N.,Pouliot, P.,Gutsche, I.,Shkumatov, A.V.,Tarbouriech, N.,Verstraete, K.,Bekaert, A.,Burmeister, W.P.,Svergun, D.I.,Lambrecht, B.N.,Vergauwen, B.,Savvides, S.N.; Allosteric Competitive Inactivation of Hematopoietic Csf-1 Signaling by the Viral Decoy Receptor Barf1.; Nat.Struct.Mol.Biol., 19:938-, 2012; PubMed: 22902366; DOI: 10.1038/NSMB.2367

実験手法

X-RAY DIFFRACTION (4.4 Å)