4ACQ

Alpha-2 Macroglobulin

Summary for 4ACQ

Related1BV8
DescriptorALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE (3 entities in total)
Functional Keywordshydrolase inhibitor, proteinase inhibitor, irreversible proteinase inhibitor, conformational change, blood plasma inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight654654.98
Authors
Marrero, A.,Duquerroy, S.,Trapani, S.,Goulas, T.,Guevara, T.,Andersen, G.R.,Navaza, J.,Sottrup-Jensen, L.,Gomis-Ruth, F.X. (deposition date: 2011-12-17, release date: 2012-02-22, Last modification date: 2019-01-30)
Primary citation
Marrero, A.,Duquerroy, S.,Trapani, S.,Goulas, T.,Guevara, T.,Andersen, G.R.,Navaza, J.,Sottrup-Jensen, L.,Gomis-Ruth, F.X.
The crystal structure of human alpha 2-macroglobulin reveals a unique molecular cage.
Angew. Chem. Int. Ed. Engl., 51:3340-3344, 2012
PubMed: 22290936 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201108015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.3118 4.4% 14.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution