4AAW

S.pneumoniae GlmU in complex with an antibacterial inhibitor

Summary for 4AAW

• Entry DOI: 10.2210/pdb4aaw/pdb
• Related: 4AA7
• Descriptor: BIFUNCTIONAL PROTEIN GLMU, 4-{[1-(2-{[({5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl}sulfonyl)amino]methyl}phenyl)piperidin-4-yl]methoxy}-4-oxobutanoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase, transferase inhibitor complex
• Biological source: STREPTOCOCCUS PNEUMONIAE
• Cellular location: Cytoplasm : Q8DQ18
• Total number of polymer chains: 1
• Total formula weight: 50213.21

Authors

Otterbein, L.,Breed, J.,Ogg, D.J. (deposition date: 2011-12-05, release date: 2012-02-15, Last modification date: 2023-12-20)

• Primary citation: Green, O.M.,McKenzie, A.R.,Shapiro, A.B.,Otterbein, L.,Ni, H.,Patten, A.,Stokes, S.,Albert, R.,Kawatkar, S.,Breed, J.; Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series.; Bioorg.Med.Chem.Lett., 22:1510-, 2012; PubMed: 22297115; DOI: 10.1016/J.BMCL.2012.01.016

Experimental method

X-RAY DIFFRACTION (2.2 Å)