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4AAW

S.pneumoniae GlmU in complex with an antibacterial inhibitor

Summary for 4AAW
Entry DOI10.2210/pdb4aaw/pdb
Related4AA7
DescriptorBIFUNCTIONAL PROTEIN GLMU, 4-{[1-(2-{[({5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl}sulfonyl)amino]methyl}phenyl)piperidin-4-yl]methoxy}-4-oxobutanoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywordstransferase, transferase inhibitor complex
Biological sourceSTREPTOCOCCUS PNEUMONIAE
Cellular locationCytoplasm : Q8DQ18
Total number of polymer chains1
Total formula weight50213.21
Authors
Otterbein, L.,Breed, J.,Ogg, D.J. (deposition date: 2011-12-05, release date: 2012-02-15, Last modification date: 2023-12-20)
Primary citationGreen, O.M.,McKenzie, A.R.,Shapiro, A.B.,Otterbein, L.,Ni, H.,Patten, A.,Stokes, S.,Albert, R.,Kawatkar, S.,Breed, J.
Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series.
Bioorg.Med.Chem.Lett., 22:1510-, 2012
Cited by
PubMed: 22297115
DOI: 10.1016/J.BMCL.2012.01.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

221051

數據於2024-06-12公開中

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