4A9C

Crystal structure of human SHIP2 in complex with biphenyl 2,3',4,5',6- pentakisphosphate

Summary for 4A9C

• Entry DOI: 10.2210/pdb4a9c/pdb
• Descriptor: PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2, BIPHENYL 2,3',4,5',6-PENTAKISPHOSPHATE (3 entities in total)
• Functional Keywords: sgc, phosphatidylinositol, signalling, structural genomics consortium stockholm, magnesium binding, hydrolase, inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm, cytosol: O15357
• Total number of polymer chains: 2
• Total formula weight: 73121.81

Authors

Tresaugues, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Edwards, A.M.,Ekblad, T.,Graslund, S.,Karlberg, T.,Mills, S.J.,Moche, M.,Nyman, T.,Persson, C.,Potter, B.V.L.,Schuler, H.,Thorsell, A.G.,Weigelt, J.,Nordlund, P. (deposition date: 2011-11-25, release date: 2012-05-30, Last modification date: 2023-12-20)

• Primary citation: Mills, S.J.,Persson, C.,Cozier, G.,Thomas, M.P.,Tresaugues, L.,Erneux, C.,Riley, A.M.,Nordlund, P.,Potter, B.V.L.; A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with Ship2 Provides a Rationale for Drug Discovery.; Acs Chem.Biol., 7:822-, 2012; PubMed: 22330088; DOI: 10.1021/CB200494D

Experimental method

X-RAY DIFFRACTION (2.1 Å)