4A4L

CRYSTAL STRUCTURE OF POLO-LIKE KINASE 1 IN COMPLEX WITH A 5-(2-AMINO- PYRIMIDIN-4-YL)-1H-PYRROLE INHIBITOR

4A4L の概要

関連するPDBエントリー1UMW 2V5Q 1Q4K 4A4O 2YAC 1Q4O
分子名称SERINE/THREONINE-PROTEIN KINASE PLK1, ZINC ION, L(+)-TARTARIC ACID, ... (5 entities in total)
機能のキーワードtransferase
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数1
分子量合計36337.49
構造登録者
Bertrand, J.A.,Bossi, R.T. (登録日: 2011-10-17, 公開日: 2012-01-11, 最終更新日: 2019-04-03)
主引用文献
Caruso, M.,Valsasina, B.,Ballinari, D.,Bertrand, J.A.,Brasca, M.G.,Caldarelli, M.,Cappella, P.,Fiorentini, F.,Gianellini, L.M.,Scolaro, A.,Beria, I.
5-(2-Amino-Pyrimidin-4-Yl)-1H-Pyrrole and 2-(2-Amino-Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolo[3,2-C]Pyridin-4-One Derivatives as New Classes of Selective and Orally Available Polo-Like Kinase 1 Inhibitors.
Bioorg.Med.Chem.Lett., 22:96-, 2012
PubMed: 22154349 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.BMCL.2011.11.065
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.35 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21911 1.4% 3.1% 3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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