4A46

Crosstalk between Cu(I) and Zn(II) homeostasis

4A46 の概要

• エントリーDOI: 10.2210/pdb4a46/pdb
• 関連するPDBエントリー: 1SB6 2XMJ 2XMK 2XMM 2XMT 2XMU 2XMV 4A47 4A48
• 分子名称: SSR2857 PROTEIN, ZINC ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: transport protein, copper homeostasis, zinc homeostasis, metal-transporting atpases
• 由来する生物種: SYNECHOCYSTIS SP. PCC 6803
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 26484.97

構造登録者

Badarau, A.,Basle, A.,Firbank, S.J.,Denninson, C. (登録日: 2011-10-07, 公開日: 2012-12-12, 最終更新日: 2023-12-20)

主引用文献

Badarau, A.,Basle, A.,Firbank, S.J.,Dennison, C.
Crosstalk between Cu(I) and Zn(II) Homeostasis Via Atx1 and Cognate Domains.
Chem.Commun.(Camb.), 49:8000-, 2013

PubMed Abstract: The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.

PubMed: 23926594
DOI: 10.1039/C3CC42709A

実験手法

X-RAY DIFFRACTION (1.85 Å)