4ZZ0
Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)
Summary for 4ZZ0
Entry DOI | 10.2210/pdb4zz0/pdb |
Related | 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ1 4ZZ2 4ZZ3 |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid, ... (4 entities in total) |
Functional Keywords | gar transformylase, antifolate, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 23515.75 |
Authors | Deis, S.M.,Dann III, C.E. (deposition date: 2015-05-22, release date: 2016-04-20, Last modification date: 2023-09-27) |
Primary citation | Deis, S.M.,Doshi, A.,Hou, Z.,Matherly, L.H.,Gangjee, A.,Dann, C.E. Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. Biochemistry, 55:4574-4582, 2016 Cited by PubMed: 27439469DOI: 10.1021/acs.biochem.6b00412 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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