4ZWX

Engineered Carbonic Anhydrase IX mimic in complex with glucosyl sulfamate inhibitor

Summary for 4ZWX

Entry DOI	10.2210/pdb4zwx/pdb
Related	4ZWI 4ZWY 4ZWZ 4ZX0 4ZX1
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	carbonic anhydrase ix mimic, glucosyl sulfamate, complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29642.73
Authors	Mahon, B.P.,Lomelino, C.L.,Salguero, A.L.,McKenna, R. (deposition date: 2015-05-19, release date: 2015-10-28, Last modification date: 2024-03-06)
Primary citation	Mahon, B.P.,Lomelino, C.L.,Ladwig, J.,Rankin, G.M.,Driscoll, J.M.,Salguero, A.L.,Pinard, M.A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A.,McKenna, R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. J.Med.Chem., 58:6630-6638, 2015 Cited by PubMed: 26203869 DOI: 10.1021/acs.jmedchem.5b00845 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.696 Å)

Structure validation