4ZOL
Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex
Summary for 4ZOL
Entry DOI | 10.2210/pdb4zol/pdb |
Related | 4ZHQ 4ZI7 5BMV |
Related PRD ID | PRD_002237 |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (2R,4R)-4-{[(2-{(1R,3R)-1-(acetyloxy)-4-methyl-3-[methyl(N-{[(2S)-1-methylpiperidin-2-yl]carbonyl}-D-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid, ... (13 entities in total) |
Functional Keywords | structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cytoplasm, cytoskeleton: Q2XVP4 P02554 Golgi apparatus : P63043 |
Total number of polymer chains | 6 |
Total formula weight | 266553.47 |
Authors | |
Primary citation | Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol., 89:233-242, 2016 Cited by PubMed: 26660762DOI: 10.1124/mol.115.100149 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report