4ZAU
AZD9291 complex with wild type EGFR
Summary for 4ZAU
Entry DOI | 10.2210/pdb4zau/pdb |
Related | 4WRG |
Descriptor | Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide (3 entities in total) |
Functional Keywords | transferase, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38063.06 |
Authors | Squire, C.J.,Yosaatmadja, Y.,Flanagan, J.U.,McKeage, M. (deposition date: 2015-04-14, release date: 2015-11-11, Last modification date: 2023-09-27) |
Primary citation | Yosaatmadja, Y.,Silva, S.,Dickson, J.M.,Patterson, A.V.,Smaill, J.B.,Flanagan, J.U.,McKeage, M.J.,Squire, C.J. Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed. J.Struct.Biol., 192:539-544, 2015 Cited by PubMed: 26522274DOI: 10.1016/j.jsb.2015.10.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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