4ZAE
Development of a novel class of potent and selective FIXa inhibitors
Summary for 4ZAE
Entry DOI | 10.2210/pdb4zae/pdb |
Descriptor | Coagulation factor IX, 2,6-dichloro-N-[(2R)-2-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-phenylethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ... (6 entities in total) |
Functional Keywords | serine proteinase, blood coagulation, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted : P00740 P00740 |
Total number of polymer chains | 2 |
Total formula weight | 33682.19 |
Authors | Hruza, A.,Reichert, P. (deposition date: 2015-04-13, release date: 2015-06-03, Last modification date: 2023-09-27) |
Primary citation | Zhang, T.,Andre, P.,Bateman, T.J.,Chen, Y.H.,Desai, K.,Ellsworth, K.,Geissler, W.M.,Guo, L.,Hruza, A.,Jian, T.,Meng, D.,Parker, D.L.,Qian, X.,Reichert, P.,Sherer, E.C.,Shu, M.,Smith, C.J.,Sonatore, L.M.,Tschirret-Guth, R.,Nolting, A.F.,Orr, R.,Campeau, L.C.,Araki, K.,Nishimura, T.,Sakurada, I.,Wood, H.B. Development of a novel class of potent and selective FIXa inhibitors. Bioorg.Med.Chem.Lett., 25:4945-4949, 2015 Cited by PubMed: 25978966DOI: 10.1016/j.bmcl.2015.04.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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