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5DOY

Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution

This is a non-PDB format compatible entry.
Replaces:  4Z3Q
Summary for 5DOY
Entry DOI10.2210/pdb5doy/pdb
Related4Z3S 5DOX
Descriptor23S Ribosomal RNA, 50S Ribosomal Protein L14, 50S Ribosomal Protein L15, ... (62 entities in total)
Functional Keywordshygromycin a, a201a, antibiotic, 70s ribosome, inhibition of translation, peptidyl transferase inhibitors, trna accommodation intermediate, single-molecule fret, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceEscherichia coli
More
Total number of polymer chains112
Total formula weight4561674.42
Authors
Polikanov, Y.S.,Starosta, A.L.,Juette, M.F.,Altman, R.B.,Terry, D.S.,Lu, W.,Burnett, B.J.,Dinos, G.,Reynolds, K.,Blanchard, S.C.,Steitz, T.A.,Wilson, D.N. (deposition date: 2015-09-11, release date: 2015-12-30, Last modification date: 2023-11-15)
Primary citationPolikanov, Y.S.,Starosta, A.L.,Juette, M.F.,Altman, R.B.,Terry, D.S.,Lu, W.,Burnett, B.J.,Dinos, G.,Reynolds, K.A.,Blanchard, S.C.,Steitz, T.A.,Wilson, D.N.
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58:832-844, 2015
Cited by
PubMed: 26028538
DOI: 10.1016/j.molcel.2015.04.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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