4YQV
Glutathione S-transferase Omega 1 bound to covalent inhibitor C4-10
Summary for 4YQV
Entry DOI | 10.2210/pdb4yqv/pdb |
Related | 4YQM 4YQU |
Descriptor | Glutathione S-transferase omega-1, 2-(ethylsulfanyl)-N-methyl-N-[(1-phenyl-1H-pyrazol-4-yl)methyl]acetamide (3 entities in total) |
Functional Keywords | covalent inhibitor, thioltransferase, chloroacetamide, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P78417 |
Total number of polymer chains | 3 |
Total formula weight | 84484.50 |
Authors | Stuckey, J.A. (deposition date: 2015-03-13, release date: 2016-10-12, Last modification date: 2023-09-27) |
Primary citation | Ramkumar, K.,Samanta, S.,Kyani, A.,Yang, S.,Tamura, S.,Ziemke, E.,Stuckey, J.A.,Li, S.,Chinnaswamy, K.,Otake, H.,Debnath, B.,Yarovenko, V.,Sebolt-Leopold, J.S.,Ljungman, M.,Neamati, N. Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor. Nat Commun, 7:13084-13084, 2016 Cited by PubMed: 27703239DOI: 10.1038/ncomms13084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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