4YOI
Structure of HKU4 3CLpro bound to non-covalent inhibitor 1A
Summary for 4YOI
Entry DOI | 10.2210/pdb4yoi/pdb |
Related | 4YO9 4YOG 4YOJ |
Descriptor | 3C-like proteinase, N-{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl}thiophene-2-carboxamide, ACETATE ION, ... (5 entities in total) |
Functional Keywords | hku4 3clpro mpro nsp5, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bat coronavirus HKU4 (BtCoV) |
Total number of polymer chains | 2 |
Total formula weight | 67691.05 |
Authors | St John, S.E.,Mesecar, A. (deposition date: 2015-03-11, release date: 2015-08-05, Last modification date: 2024-02-28) |
Primary citation | St John, S.E.,Tomar, S.,Stauffer, S.R.,Mesecar, A.D. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4-The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorg.Med.Chem., 23:6036-6048, 2015 Cited by PubMed: 26190463DOI: 10.1016/j.bmc.2015.06.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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