4Y79
Factor Xa complex with GTC000406
Summary for 4Y79
Entry DOI | 10.2210/pdb4y79/pdb |
Descriptor | Coagulation factor X, CALCIUM ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | hydrolase, inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 44267.70 |
Authors | Convery, M.A.,Young, R.J.,Senger, S.,Hamblin, J.N.,Chan, C.,Toomey, J.R.,Watson, N.S. (deposition date: 2015-02-13, release date: 2015-09-30, Last modification date: 2024-01-10) |
Primary citation | Chan, C.,Borthwick, A.D.,Brown, D.,Burns-Kurtis, C.L.,Campbell, M.,Chaudry, L.,Chung, C.W.,Convery, M.A.,Hamblin, J.N.,Johnstone, L.,Kelly, H.A.,Kleanthous, S.,Patikis, A.,Patel, C.,Pateman, A.J.,Senger, S.,Shah, G.P.,Toomey, J.R.,Watson, N.S.,Weston, H.E.,Whitworth, C.,Young, R.J.,Zhou, P. Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides. J. Med. Chem., 50:1546-1557, 2007 Cited by PubMed: 17338508DOI: 10.1021/jm060870c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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