4XXR
Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase
Summary for 4XXR
Entry DOI | 10.2210/pdb4xxr/pdb |
Descriptor | CTX-M-14 Class A Beta-Lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (6 entities in total) |
Functional Keywords | beta-lactamase organometallic ruthenocene ctx-m-14, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 59106.29 |
Authors | Lewandowski, E.M.,Chen, Y. (deposition date: 2015-01-30, release date: 2015-03-18, Last modification date: 2023-09-27) |
Primary citation | Lewandowski, E.M.,Skiba, J.,Torelli, N.J.,Rajnisz, A.,Solecka, J.,Kowalski, K.,Chen, Y. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic. Chem.Commun.(Camb.), 51:6186-6189, 2015 Cited by PubMed: 25753149DOI: 10.1039/c5cc00904a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
Download full validation report