4X3R
Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor
Summary for 4X3R
Entry DOI | 10.2210/pdb4x3r/pdb |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | glycoprotein, metallopeptidase, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 87653.81 |
Authors | Tykvart, J.,Konvalinka, J. (deposition date: 2014-12-01, release date: 2015-10-14, Last modification date: 2024-01-10) |
Primary citation | Tykvart, J.,Schimer, J.,Jancarik, A.,Barinkova, J.,Navratil, V.,Starkova, J.,Sramkova, K.,Konvalinka, J.,Majer, P.,Sacha, P. Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II. J.Med.Chem., 58:4357-4363, 2015 Cited by PubMed: 25923815DOI: 10.1021/acs.jmedchem.5b00278 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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