4WWP
Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Summary for 4WWP
Entry DOI | 10.2210/pdb4wwp/pdb |
Related | 4WWN 4WWO |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, ... (5 entities in total) |
Functional Keywords | kinase, phosphotransfer, pip2, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110563.16 |
Authors | Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2014-11-11, release date: 2014-12-17, Last modification date: 2024-02-28) |
Primary citation | Cushing, T.D.,Hao, X.,Shin, Y.,Andrews, K.,Brown, M.,Cardozo, M.,Chen, Y.,Duquette, J.,Fisher, B.,Gonzalez-Lopez de Turiso, F.,He, X.,Henne, K.R.,Hu, Y.L.,Hungate, R.,Johnson, M.G.,Kelly, R.C.,Lucas, B.,McCarter, J.D.,McGee, L.R.,Medina, J.C.,San Miguel, T.,Mohn, D.,Pattaropong, V.,Pettus, L.H.,Reichelt, A.,Rzasa, R.M.,Seganish, J.,Tasker, A.S.,Wahl, R.C.,Wannberg, S.,Whittington, D.A.,Whoriskey, J.,Yu, G.,Zalameda, L.,Zhang, D.,Metz, D.P. Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58:480-511, 2015 Cited by PubMed: 25469863DOI: 10.1021/jm501624r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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