4WUQ
Crystal structure of human carbonic anhydrase isozyme I with 2,3,5,6-Tetrafluoro-4-piperidin-1-ylbenzenesulfonamide
Summary for 4WUQ
Entry DOI | 10.2210/pdb4wuq/pdb |
Related | 4WR7 4WUP |
Descriptor | Carbonic anhydrase 1, ZINC ION, 2,3,5,6-tetrafluoro-4-(piperidin-1-yl)benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00915 |
Total number of polymer chains | 2 |
Total formula weight | 58531.72 |
Authors | Manakova, E.,Smirnov, A.,Grazulis, S. (deposition date: 2014-11-03, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Zubriene, A.,Smirnoviene, J.,Smirnov, A.,Morkunaite, V.,Michailoviene, V.,Jachno, J.,Juozapaitiene, V.,Norvaisas, P.,Manakova, E.,Grazulis, S.,Matulis, D. Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry. Biophys.Chem., 205:51-65, 2015 Cited by PubMed: 26079542DOI: 10.1016/j.bpc.2015.05.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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