4WGI

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

Summary for 4WGI

Entry DOI	10.2210/pdb4wgi/pdb
Related PRD ID	PRD_900001
Descriptor	Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ... (6 entities in total)
Functional Keywords	fusion protein, mbp, transport protein, transport protein-inhibitor complex, apoptosis-inhibitor complex, apoptosis/inhibitor
Biological source	Escherichia coli O157:H7 More
Total number of polymer chains	1
Total formula weight	58804.38
Authors	Clifton, M.C.,Fairman, J.W.,Fang, C.,D'Souza, B.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Kaushik, V.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H. (deposition date: 2014-09-18, release date: 2014-11-19, Last modification date: 2023-09-27)
Primary citation	Fang, C.,D'Souza, B.,Thompson, C.F.,Clifton, M.C.,Fairman, J.W.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Feau, C.,Kaushik, V.K.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H. Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). Acs Med.Chem.Lett., 5:1308-1312, 2014 Cited by PubMed: 25516789 DOI: 10.1021/ml500388q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation