4UHA
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(methyl(2-(methylamino)ethyl)amino)benzonitrile
Summary for 4UHA
Entry DOI | 10.2210/pdb4uha/pdb |
Related | 4UGZ 4UH0 4UH1 4UH2 4UH3 4UH4 4UH5 4UH6 4UH7 4UH8 4UH9 |
Descriptor | NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | oxidoreductase, inhibitor complex |
Biological source | BOS TAURUS (CATTLE) |
Total number of polymer chains | 2 |
Total formula weight | 102302.14 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2015-03-23, release date: 2015-07-15, Last modification date: 2019-01-30) |
Primary citation | Kang, S.,Li, H.,Tang, W.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J. Med. Chem., 58:5548-5560, 2015 Cited by PubMed: 26120733DOI: 10.1021/acs.jmedchem.5b00573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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